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Methods and Compositions for Prevention and Treatment of Acute Radiation Syndromes (ARS)

USPTO Provisional Application 508315653

Therapeutic methods and compositions useful for the prevention and/or treatment of mammalian tissue including cell organelle membrane damage resulting from ionizing radiation leading to generation of reactive oxygen species that chemically alter cell membrane phospholipids resulting in breakdown of the barrier function of the cellular membrane and also alter cell protein structure resulting in loss of cell viability. A therapeutic composition includes a combination of a water structure altering radiation resistant surfactant and either a cofactor treatment consisting of an antioxidant or a cellular energy store or both. To affect this goal, the barrier properties of damaged cellular membranes are reestablished by the membrane sealing surfactant, effectively “sealing” the injured membranes. To facilitate rapid tissue recovery, cellular energy levels can be reestablished through addition of a cellular energy source such as, for example, MgCl2-ATP which, serves a further dual benefit of improving the cellular ion balance. Addition of an antioxidant eliminates the generation or destructiveness of reactive oxygen intermediates (ROIs) and enhances the safe metabolism of free radicals.

Materials and Methods of Treating Viral Infection with Amphiphilic Block Copolymers

Patent US-2024024354-A1